Resveratrol is a polyphenol molecule that may be found in a variety of plants. The interest in this compound has skyrocketed in recent decades as benefits on metabolism and increased lifespan of various organisms have been reported with its supplementation.
Several in-vitro and animal investigations have shown that レスベラトロール can operate on a variety of molecular targets, including sit-ins, a kind of NAD + -dependent deacetylase.
Despite the positive outcomes reported in numerous animal and in-vitro investigations, few human trials have been conducted with conflicting results. These disparities in data may be due, at least in part, to differences in the characteristics of the patients enrolled, dosages, and supplementation duration.
The so-called “French Paradox” is responsible for the popularity of resveratrol. The phrase originated in the early 1990s as a result of the discovery that, despite a high dietary consumption of saturated fatty acids, French people had a comparatively low incidence of coronary heart disease when compared to corresponding-age individuals from other Western nations.
The French scientist Renaud ascribed this paradox to increased red wine intake, and later, theハイブリッドレスベラトロール安く買う component of wine was found as one of the putative mechanisms of red wine advantages. Since then, there has been a surge in interest in this natural substance.
Since 1997, when its anti-cancer capabilities were identified, research has turned from human to animal models, and the number of studies on resveratrol has expanded dramatically. Several writers have explored resveratrol’s potential cardioprotective, anti-cancer, anti-inflammatory, and antioxidant effects. In animal and in vitro investigations, resveratrol has been shown to have a wide range of positive benefits, as well as several probable direct or indirect molecular targets and methods of action. Only recently, research has concentrated on people again, and thus far a handful of human clinical trial have been undertaken.
In the early 2000s, several researchers found that resveratrol can imitate calorie restriction effects and improve the longevity of yeast, worms, flies, and rodents. This action was attributed to resveratrol’s capacity to activate sirtuin proteins, which are NAD +-dependent de-acetylases implicated in metabolism, apoptosis, mitochondrial biogenesis, inflammation, fatty acid metabolism, and glucose homeostasis.
However, sirtuins are not the only molecular targets of resveratrol, and because of its ability to act on multiple molecular targets, resveratrol has a wide range of biological effects, including the inhibition of angiogenesis, cancer cell and metastatic cell growth, the improvement of vascular function, arterial blood pressure values, and platelet aggregation, and anti-inflammatory.
Finally, another intriguing but unresolved issue is the probable effect of the dietary matrix on resveratrol bioavailability in humans. Some authors have demonstrated that trans-resveratrol is better absorbed when taken in the form of wine or grape juice rather than tablets; in vivo bioavailability and bioactivity may be increased by the food matrix due to the presence of other natural compounds, such as other polyphenols, which appear to play a synergistic role in increasing resveratrol bioactivity.
The diverse effects of ハイブリッドレスベラトロール discovered in hybridresvera in vitro and animal investigations have yet to be definitively verified in human studies. At the moment, resveratrol should be assumed by natural foods, mostly by moderate consumption of red wine, grape juice, or peanuts, since supplement use is not justified by available scientific research. Many questions remain unanswered, and a resveratrol formulation that is as beneficial in people as it is in mice has yet to be developed.