TUDCA is an emerging star in functional medicine, with potential applications ranging from brain and liver health to mitochondrial and cellular support.
This edition of Health Journal delves into the complexities of liver health and its relevance and advice for long-term liver function preservation.
What is TUDCA?
TUDCA is produced as a byproduct of bile acid metabolism. Microorganisms create TUDCA, as they do many other compounds in your body.
The bile duct in the liver first transports bile salts to the digestive system. Bacteria in the large intestine convert bile salts to ursodeoxycholic acid (UDCA). TUDCA is then synthesized by combining it with the amino acid taurine. When you have enough bile salts, your body can do this function properly.
Enterohepatic circulation (when bile is absorbed by the intestines and returned to the liver through the hepatic portal vein) recycles around 95% of a healthy person’s bile salts, resulting in just a tiny amount of TUDCA production. However, poor diet, impaired liver function, and some medicines may all hinder this process.
Even though people only create a trace quantity of TUDCA, this bile salt controls various biological systems, including brain and kidney function, eye health, etc.
Although there is no standard beginning dose for TUDCA, research in adults has shown that amounts ranging from 250 to 1500 mg are helpful.BodyBio TUDCA capsules contain 250 mg (two capsules twice daily with meals is the recommended dose). It is not recommended to take more than 1500 mg each day. Never self-medicate; instead, get medical guidance on the appropriate dosage.
TUDCA is an efficient bile acid that performs its purpose well. TUDCA has several applications and benefits, but humans only produce a small amount. TUDCA is expected to approve.
Supports Insulin Sensitivity
Endoplasmic reticulum (ER) stress, sometimes known as “ER stress,” may have a role in several unrelated illnesses and health issues, including diabetes. TUDCA therapy, for example, resulted in a 43% drop in blood glucose in rats with chemically induced increased blood sugar in one study.
Bile acids are widely known to have an essential function in digestion. However, they also serve as signaling molecules in a variety of organs. Organs. The pancreas is an example of such an organ since it creates receptors that regulate various cellular functions, including blood sugar.
TUDCA has been shown in studies with obese, overfed rats to maintain appropriate blood sugar levels and enhance insulin sensitivity, while the consequences for weight loss are yet uncertain.
Nootropics, often known as cognitive enhancers, have witnessed a stratospheric surge in popularity in recent years. TUDCA may be the appropriate solution for needing memory and brain function aid. TUDCA has been intensively researched for its possible neuroprotective qualities and has been shown to cross the blood-brain barrier.
The TUDCA molecule is a member of a class of molecules known as chemical chaperones. You may think of them as compounds that aid the body’s production and distribution of proteins. TUDCA has been found in studies to be effective in this capacity since it provides aid to several systems simultaneously.* It also helps to maintain mitochondrial integrity and inhibits cell death in numerous mice models of neurological illness. TUDCA aids in the preservation of neurons as we age.
TUDCA is generally helpful to the liver. In a clinical experiment, people with liver cirrhosis and high liver enzymes were given TUDCA (750 mg) for six months. TUDCA reduced liver enzymes in every single person who took it. Furthermore, the study participants tolerated the bile acid supplement well, with no side effects.
Supports Genetic Expression
Surprisingly, TUDCA may influence gene expression and DNA. TUDCA may protect DNA from damage by reducing oxidative stress, increasing mitochondrial activity, and regulating apoptosis.
TUDCA has been proven in vitro to improve cell survival by inhibiting DNA fragmentation in neuronal cells.
The mitochondria in your cells are the cell’s principal energy source. These tiny organelles produce about 90% of the energy that keeps us alive. When mitochondria fail to function correctly, our bodies cannot create enough of our energy currency, adenosine triphosphate (ATP).
TUDCA has been shown to improve mitochondrial health and energy production by enhancing antioxidant production and lowering reactive oxygen species (free radicals) at the root of many chronic disorders.
TUDCA Side Effects
TUDCA pills are regarded to be safe when taken at the recommended dosage. However, several studies have shown that more than 1500 mg daily causes diarrhea. TUDCA has just one known side effect; no others have been reported.
Pregnant or nursing women are not suggested to take TUDCA supplements due to a lack of research on its safety.
TUDCA may interact with other medications; thus, people with pre-existing conditions should see their doctor before beginning therapy.
Never add dietary supplements to your routine without first seeing your doctor. They can tell you whether or not enrolling in TUDCA will benefit you.
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